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Chiral Nanoporous Metal-Organic Frameworks with High Porosity as Materials for Drug Delivery

Authors

  • Chun-Yi Sun,

    1. Institute of Functional Materials Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education, Department of Chemistry, Northeast Normal University Changchun, Jilin, 130024, China
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  • Chao Qin,

    1. Institute of Functional Materials Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education, Department of Chemistry, Northeast Normal University Changchun, Jilin, 130024, China
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  • Chun-Gang Wang,

    1. Institute of Functional Materials Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education, Department of Chemistry, Northeast Normal University Changchun, Jilin, 130024, China
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  • Zhong-Min Su,

    Corresponding author
    1. Institute of Functional Materials Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education, Department of Chemistry, Northeast Normal University Changchun, Jilin, 130024, China
    • Institute of Functional Materials Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education, Department of Chemistry, Northeast Normal University Changchun, Jilin, 130024, China.
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  • Shuang Wang,

    1. Institute of Functional Materials Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education, Department of Chemistry, Northeast Normal University Changchun, Jilin, 130024, China
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  • Xin-Long Wang,

    Corresponding author
    1. Institute of Functional Materials Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education, Department of Chemistry, Northeast Normal University Changchun, Jilin, 130024, China
    • Institute of Functional Materials Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education, Department of Chemistry, Northeast Normal University Changchun, Jilin, 130024, China.
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  • Guang-Sheng Yang,

    1. Institute of Functional Materials Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education, Department of Chemistry, Northeast Normal University Changchun, Jilin, 130024, China
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  • Kui-Zhan Shao,

    1. Institute of Functional Materials Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education, Department of Chemistry, Northeast Normal University Changchun, Jilin, 130024, China
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  • Ya-Qian Lan,

    1. Institute of Functional Materials Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education, Department of Chemistry, Northeast Normal University Changchun, Jilin, 130024, China
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  • En-Bo Wang

    1. Institute of Functional Materials Chemistry, Key Laboratory of Polyoxometalate Science of Ministry of Education, Department of Chemistry, Northeast Normal University Changchun, Jilin, 130024, China
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Abstract

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A chiral nanoporous metal-organic framework (MOF) with high porosity is obtained based on nontoxic zinc and achiral hexadentate ligand. It shows high drug loading and slow release of the proportion of the loaded drug with a complete delivery time of about one week when used as a material for adsorption and delivery of anticancer 5-fluorouracil.

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