Communication

Controlled Synthesis of 3D Multi-Compartmental Particles with Centrifuge-Based Microdroplet Formation from a Multi-Barrelled Capillary

  1. Kazuki Maeda1,
  2. Hiroaki Onoe1,2,
  3. Masahiro Takinoue1,†,
  4. Shoji Takeuchi1,2,*

Article first published online: 6 FEB 2012

DOI: 10.1002/adma.201102560

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 10, pages 1340–1346, March 8, 2012

Additional Information

How to Cite

Maeda, K., Onoe, H., Takinoue, M. and Takeuchi, S. (2012), Controlled Synthesis of 3D Multi-Compartmental Particles with Centrifuge-Based Microdroplet Formation from a Multi-Barrelled Capillary. Adv. Mater., 24: 1340–1346. doi: 10.1002/adma.201102560

Author Information

  1. 1

    Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan

  2. 2

    Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST), 4-6-1, Komaba, Meguro-ku, Tokyo 153-8505, Japan

  1. †

    Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan

*Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.

Publication History

  1. Issue published online: 6 MAR 2012
  2. Article first published online: 6 FEB 2012
  3. Manuscript Revised: 7 NOV 2011
  4. Manuscript Received: 5 JUL 2011

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Keywords:

  • anisotropic particles;
  • microfabrication;
  • microfluidics;
  • hydrogels;
  • cell-encapsulation
Thumbnail image of graphical abstract

Controlled synthesis of micro multi-compartmental particles using a centrifuge droplet shooting device (CDSD) is reported. Sodium alginate solutions introduced in a multi-barreled capillary form droplets at the capillary orifice under ultrahigh gravity and gelify in a CaCl2 solution. The size, shape, and compartmentalization of the particles are controlled. Co-encapsulation of Jurkat cells and magnetic colloids into Janus particles is demonstrated. The Janus particles present sensitive reaction toward magnetic fields, while the viability of the encapsulated cells is 91%.

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