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Bio-Inspired Enamel Repair via Glu-Directed Assembly of Apatite Nanoparticles: an Approach to Biomaterials with Optimal Characteristics

Authors

  • Li Li,

    1. Centre of Biopathways and Biomaterials and Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China Fax: (+)86 571 87953736
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  • Caiyun Mao,

    1. First Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang 310003, China
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  • Jianming Wang,

    1. Centre of Biopathways and Biomaterials and Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China Fax: (+)86 571 87953736
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  • Xurong Xu,

    1. Centre of Biopathways and Biomaterials and Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China Fax: (+)86 571 87953736
    2. State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou, Zhejiang 310027, China
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  • Haihua Pan,

    1. Centre of Biopathways and Biomaterials and Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China Fax: (+)86 571 87953736
    2. State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou, Zhejiang 310027, China
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  • Yan Deng,

    1. Unilever Discover Shanghai, Changning District, 66 Linxin Road, Shanghai 200233, China
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  • Xinhua Gu,

    1. First Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang 310003, China
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  • Ruikang Tang

    Corresponding author
    1. Centre of Biopathways and Biomaterials and Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China Fax: (+)86 571 87953736
    2. State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou, Zhejiang 310027, China
    • Centre of Biopathways and Biomaterials and Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China Fax: (+)86 571 87953736.
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Abstract

original image

A biomimetic construction of enamel-like apatite material is achieved by the cooperation of nanoparticles and Glu on enamel substrate under physiological conditions; the artificial apatite layer shares the exactly same crystallographic and tectonic properties with the natural enamel; and the apparent restoration of enamel hardness is particularly significant. We suggest a biomineralization-inspired strategy to approach biomaterials with optimal characteristics.

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