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Detection of a Prognostic Indicator in Early-Stage Cancer Using Functionalized Graphene-Based Peptide Sensors

Authors

  • Lingyan Feng,

    1. Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262656
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  • Li Wu,

    1. Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262656
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  • Jiasi Wang,

    1. Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262656
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  • Jinsong Ren,

    1. Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262656
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  • Daisuke Miyoshi,

    1. Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan
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  • Naoki Sugimoto,

    1. Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan
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  • Xiaogang Qu

    Corresponding author
    1. Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262656
    • Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Laboratory of Chemical Biology, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262656.
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Abstract

Using a porphyrin-functionalized graphene-modified electrode, an electrochemical impedance peptide sensor for label-free detection of cyclin A2 has been constructed. This electrochemical sensor can not only detect protein in cancer cells but also differentiate cancer cells from normal ones. Furthermore, the assay provides the potential of using a simple electrochemical technique to estimate the efficiency of anticancer drugs in cancer therapy.

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