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“Living” Microvascular Stamp for Patterning of Functional Neovessels; Orchestrated Control of Matrix Property and Geometry

Authors

  • Jae Hyun Jeong,

    1. Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
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  • Vincent Chan,

    1. Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
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  • Chaenyung Cha,

    1. Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
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  • Pinar Zorlutuna,

    1. Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
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  • Casey Dyck,

    1. Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
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  • K. Jimmy Hsia,

    1. Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    2. Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    3. Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
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  • Rashid Bashir,

    Corresponding author
    1. Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    2. Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    3. Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    4. Institute of Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    • Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
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  • Hyunjoon Kong

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    2. Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    3. Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    4. Institute of Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    • Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
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Abstract

This study presents a “living” microvascular stamp that releases multiple angiogenic factors and subsequently creates functional neovessels with the same pattern as that engraved in the stamp. The stamp consists of live cells that secrete angiogenic factors, an engineered hydrogel matrix that promotes cellular expression of angiogenic factors, and a three-dimensional geometry that localizes the angiogenic factors within the pattern.

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