Targeting Gold Nanoshells on Silica Nanorattles: a Drug Cocktail to Fight Breast Tumors via a Single Irradiation with Near-Infrared Laser Light

Authors

  • Huiyu Liu,

    1. Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
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  • Tianlong Liu,

    1. Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
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  • Xiaoli Wu,

    1. Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
    2. Graduate University of the Chinese Academy of Sciences, Beijing 100049, P. R. China
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  • Linlin Li,

    1. Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
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  • Longfei Tan,

    1. Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
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  • Dong Chen,

    Corresponding author
    1. Beijing Creative Nanophase Hi-Tech Company, Limited, Beijing 100086, P. R. China
    • Beijing Creative Nanophase Hi-Tech Company, Limited, Beijing 100086, P. R. China
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  • Fangqiong Tang

    Corresponding author
    1. Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
    • Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
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Abstract

original image

The drug-loaded, transferrin and poly(ethylene glycol) (PEG)-functionalized gold nanoshells on silica nanorattles (pGSNs-Doc-Tf) can combine the active targeting, passive targeting, remote-controlled photothermal therapy together with chemotherapy to completely kill tumor cells via a single irradiation with near-infrared laser light.

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