Communication

Kinetically Assembled Nanoparticles of Bioactive Macromolecules Exhibit Enhanced Stability and Cell-Targeted Biological Efficacy

  1. Adam W. York1,
  2. Kyle R. Zablocki1,
  3. Daniel R. Lewis2,
  4. Li Gu3,
  5. Kathryn E. Uhrich3,
  6. Robert K. Prud'homme3,4,
  7. Prabhas V. Moghe1,2,*

Article first published online: 2 JAN 2012

DOI: 10.1002/adma.201103348

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 6, pages 733–739, February 7, 2012

Additional Information

How to Cite

York, A. W., Zablocki, K. R., Lewis, D. R., Gu, L., Uhrich, K. E., Prud'homme, R. K. and Moghe, P. V. (2012), Kinetically Assembled Nanoparticles of Bioactive Macromolecules Exhibit Enhanced Stability and Cell-Targeted Biological Efficacy. Adv. Mater., 24: 733–739. doi: 10.1002/adma.201103348

Author Information

  1. 1

    Department of Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ 08854, USA

  2. 2

    Department of Chemical and Biochemical Engineering, Rutgers University, 98 Brett Road, Piscataway, NJ 08854, USA

  3. 3

    Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, NJ 08854, USA

  4. 4

    Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA

*Department of Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ 08854, USA.

Publication History

  1. Issue published online: 31 JAN 2012
  2. Article first published online: 2 JAN 2012
  3. Manuscript Revised: 10 OCT 2011
  4. Manuscript Received: 31 AUG 2011

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Keywords:

  • nanomedicine;
  • cardiovascular disease;
  • macrophages;
  • atherosclerosis;
  • flash nanoprecipitation
Thumbnail image of graphical abstract

Kinetically assembled nanoparticles are fabricated from an advanced class of bioactive macromolecules that have potential utility in counteracting atherosclerotic plaque development via receptor-level blockage of inflammatory cells. In contrast to micellar analogs that exhibit poor potency and structural integrity under physiologic conditions, these kinetic nanoparticle assemblies maintain structural stability and demonstrate superior bioactivity in mediating oxidized low-density lipoprotein (oxLDL) uptake in inflammatory cells.

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