Communication

Shrink-Film Configurable Multiscale Wrinkles for Functional Alignment of Human Embryonic Stem Cells and their Cardiac Derivatives

  1. Aaron Chen1,
  2. Deborah K. Lieu2,
  3. Lauren Freschauf3,
  4. Valerie Lew3,
  5. Himanshu Sharma1,
  6. Jiaxian Wang4,5,
  7. Diep Nguyen3,
  8. Ioannis Karakikes5,
  9. Roger J. Hajjar5,
  10. Ajay Gopinathan6,
  11. Elliot Botvinick3,
  12. Charless C. Fowlkes7,
  13. Ronald A. Li4,5,8,*,
  14. Michelle Khine1,*

Article first published online: 8 NOV 2011

DOI: 10.1002/adma.201103463

Issue

Advanced Materials

Advanced Materials

Volume 23, Issue 48, pages 5785–5791, December 22, 2011

Additional Information

How to Cite

Chen, A., Lieu, D. K., Freschauf, L., Lew, V., Sharma, H., Wang, J., Nguyen, D., Karakikes, I., Hajjar, R. J., Gopinathan, A., Botvinick, E., Fowlkes, C. C., Li, R. A. and Khine, M. (2011), Shrink-Film Configurable Multiscale Wrinkles for Functional Alignment of Human Embryonic Stem Cells and their Cardiac Derivatives. Advanced Materials, 23: 5785–5791. doi: 10.1002/adma.201103463

Author Information

  1. 1

    Department of Chemical Engineering and Material Science, University of California, Irvine, Irvine, CA 92697, USA

  2. 2

    Department of Internal Medicine, Division of Cardiovascular Medicine, University of California, Davis, Davis, CA 95616, USA

  3. 3

    Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA

  4. 4

    Stem Cell & Regenerative Medicine Consortium, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong

  5. 5

    Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY 10029, USA

  6. 6

    School of Natural Sciences, University of California, Merced, Merced, CA 95344, USA

  7. 7

    Department of Computer Science, University of California, Irvine, Irvine, CA 92697, USA

  8. 8

    Hormone & Healthy Aging Research Center, Department of Medicine and Physiology, LKS Faculty of Medicine, University of Hong Kong, Hong Kong

*Stem Cell & Regenerative Medicine Consortium, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong

Publication History

  1. Issue published online: 15 DEC 2011
  2. Article first published online: 8 NOV 2011
  3. Manuscript Received: 7 SEP 2011

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Keywords:

  • biomimetics;
  • human embryonic stem cell derived cardiomyocytes;
  • contact guidance;
  • action potential propagation

Graphical Abstract

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A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment “wrinkles”. Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.

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