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Keywords:

  • biomimetics;
  • human embryonic stem cell derived cardiomyocytes;
  • contact guidance;
  • action potential propagation
Thumbnail image of graphical abstract

A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment “wrinkles”. Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.