Communication

Density Gradient Multilayer Polymerization for Creating Complex Tissue

  1. Jerome V. Karpiak1,
  2. Yogesh Ner2,
  3. Adah Almutairi1,2,*

Article first published online: 9 FEB 2012

DOI: 10.1002/adma.201103501

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 11, pages 1466–1470, March 15, 2012

Additional Information

How to Cite

Karpiak, J. V., Ner, Y. and Almutairi, A. (2012), Density Gradient Multilayer Polymerization for Creating Complex Tissue. Adv. Mater., 24: 1466–1470. doi: 10.1002/adma.201103501

Author Information

  1. 1

    Biomedical Sciences Program, University of California at San Diego, La Jolla, CA 92093-0600, USA

  2. 2

    Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of NanoEngineering, Materials Science and Engineering Program, University of California at San Diego, La Jolla, CA 92093-0600, USA

*Biomedical Sciences Program, University of California at San Diego, La Jolla, CA 92093-0600, USA.

Publication History

  1. Issue published online: 12 MAR 2012
  2. Article first published online: 9 FEB 2012
  3. Manuscript Received: 10 DEC 2011

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Keywords:

  • hydrogels;
  • interfaces;
  • spatial control;
  • tissue engineering
Thumbnail image of graphical abstract

An adaptable density gradient multilayer polymerization (DGMP) method facilitates simple fabrication of complex multicompartment scaffolds with structurally continuous interfaces. Solvent density liquid-liquid phase segregation compartmentalizes varied mechanical and chemical cues independently. Bulk photopolymerization produces stratified three-dimensional and two-dimensional matrices. Cells attach to patterned adhesion peptides on biomimetic 2D substrates.

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