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Advanced Materials

Density Gradient Multilayer Polymerization for Creating Complex Tissue

Authors

  • Jerome V. Karpiak,

    1. Biomedical Sciences Program, University of California at San Diego, La Jolla, CA 92093-0600, USA
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  • Yogesh Ner,

    1. Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of NanoEngineering, Materials Science and Engineering Program, University of California at San Diego, La Jolla, CA 92093-0600, USA
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  • Adah Almutairi

    Corresponding author
    1. Biomedical Sciences Program, University of California at San Diego, La Jolla, CA 92093-0600, USA
    2. Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of NanoEngineering, Materials Science and Engineering Program, University of California at San Diego, La Jolla, CA 92093-0600, USA
    • Biomedical Sciences Program, University of California at San Diego, La Jolla, CA 92093-0600, USA.
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Abstract

An adaptable density gradient multilayer polymerization (DGMP) method facilitates simple fabrication of complex multicompartment scaffolds with structurally continuous interfaces. Solvent density liquid-liquid phase segregation compartmentalizes varied mechanical and chemical cues independently. Bulk photopolymerization produces stratified three-dimensional and two-dimensional matrices. Cells attach to patterned adhesion peptides on biomimetic 2D substrates.

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