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Communication
Magnetic Nanocarriers with Tunable pH Dependence for Controlled Loading and Release of Cationic and Anionic Payloads
Article first published online: 18 NOV 2011
DOI: 10.1002/adma.201103505
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Bigall, N. C., Curcio, A., Leal, M. P., Falqui, A., Palumberi, D., Di Corato, R., Albanesi, E., Cingolani, R. and Pellegrino, T. (2011), Magnetic Nanocarriers with Tunable pH Dependence for Controlled Loading and Release of Cationic and Anionic Payloads. Adv. Mater., 23: 5645–5650. doi: 10.1002/adma.201103505
Publication History
- Issue published online: 8 DEC 2011
- Article first published online: 18 NOV 2011
- Manuscript Received: 11 SEP 2011
Keywords:
- superparamagnetic nanocarriers;
- pH-responsive materials;
- gold nanoparticles;
- magnetic nanobeads;
- siRNA delivery
Superparamagnetic nanocarriers with tunable pH dependence of the surface charge are designed by a simple co-precipitation method. By exploiting electrostatic interactions, cationic or anionic payloads can be adsorbed and desorbed depending on the pH. On three different resulting nanocarrier systems, experiments of loading and release of gold nanoparticles as well as effective siRNA loading and in vitro delivery on human cells are performed.