Advanced Materials

Plasmonic Nanobubbles Enhance Efficacy and Selectivity of Chemotherapy Against Drug-Resistant Cancer Cells

Authors

  • Ekaterina Y. Lukianova-Hleb,

    1. Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77005, USA
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  • Xiaoyang Ren,

    1. Department of Clinical Cancer Prevention, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
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  • Joseph A. Zasadzinski,

    1. Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA
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  • Xiangwei Wu,

    1. Department of Clinical Cancer Prevention, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
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  • Dmitri O. Lapotko

    Corresponding author
    1. Department of Biochemistry and Cell Biology, Department of Physics and Astronomy, Rice University, 6100 Main, MS-140, Houston, TX 77005, USA, Phone: 713-348-3708, Fax: 713-348-5154
    • Department of Biochemistry and Cell Biology, Department of Physics and Astronomy, Rice University, 6100 Main, MS-140, Houston, TX 77005, USA, Phone: 713-348-3708, Fax: 713-348-5154.
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Abstract

Plasmonic nanobubbles, new multifunctional cellular nano-agents, are selectively generated in target cancer cells with a short near-infrared laser pulse. The enhanced cellular specificity and tunable transient nature of plasmonic nanobubbles provide fast, efficient and selective dual therapeutic effects: intracellular delivery of a drug and direct mechanical destruction of cells while sparing normal cells, and reduce drug dose and overcome drug-resistance of cancer cells.

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