Plasmonic nanobubbles, new multifunctional cellular nano-agents, are selectively generated in target cancer cells with a short near-infrared laser pulse. The enhanced cellular specificity and tunable transient nature of plasmonic nanobubbles provide fast, efficient and selective dual therapeutic effects: intracellular delivery of a drug and direct mechanical destruction of cells while sparing normal cells, and reduce drug dose and overcome drug-resistance of cancer cells.
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