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Advanced Materials

Coupling Electrodeposition with Layer-by-Layer Assembly to Address Proteins within Microfluidic Channels

Authors

  • Yifeng Wang,

    1. School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, 430070, PR China
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  • Yi Liu,

    1. Institute for Bioscience and Biotechnology Research and Fischell Department of Bioengineering, University of Maryland, 5115 Plant Sciences Building, College Park, MD 20742, USA
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  • Yi Cheng,

    1. Institute for Systems Research and Department of Materials Science and Engineering, University of Maryland, College Park, MD 20742, USA
    Current affiliation:
    1. These authors contributed equally to the manuscript.
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  • Eunkyoung Kim,

    1. Institute for Bioscience and Biotechnology Research and Fischell Department of Bioengineering, University of Maryland, 5115 Plant Sciences Building, College Park, MD 20742, USA
    Current affiliation:
    1. These authors contributed equally to the manuscript.
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  • Gary W. Rubloff,

    1. Institute for Systems Research and Department of Materials Science and Engineering, University of Maryland, College Park, MD 20742, USA
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  • William E. Bentley,

    1. Institute for Bioscience and Biotechnology Research and Fischell Department of Bioengineering, University of Maryland, 5115 Plant Sciences Building, College Park, MD 20742, USA
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  • Gregory F. Payne

    Corresponding author
    1. Institute for Bioscience and Biotechnology Research and Fischell Department of Bioengineering, University of Maryland, 5115 Plant Sciences Building, College Park, MD 20742, USA
    • Institute for Bioscience and Biotechnology Research and Fischell Department of Bioengineering, University of Maryland, 5115 Plant Sciences Building, College Park, MD 20742, USA.
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Abstract

Two thin-film assembly methods are coupled to address proteins. Electrodeposition confers programmability and generates a template for layer-by-layer (LbL) assembly. LbL enables precise control of film thickness and the incorporation of labile biological components. The capabilities are demonstrated using glucose oxidase (GOx) based electrochemical biosensing within a microfabricated fluidic device.

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