Communication

Hemostatic Multilayer Coatings

  1. Anita Shukla1,2,
  2. Jean C. Fang1,2,
  3. Sravanthi Puranam3,
  4. Flemming R. Jensen4,
  5. Paula T. Hammond1,2,*

Article first published online: 27 DEC 2011

DOI: 10.1002/adma.201103794

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 4, pages 492–496, January 24, 2012

Additional Information

How to Cite

Shukla, A., Fang, J. C., Puranam, S., Jensen, F. R. and Hammond, P. T. (2012), Hemostatic Multilayer Coatings. Adv. Mater., 24: 492–496. doi: 10.1002/adma.201103794

Author Information

  1. 1

    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA

  2. 2

    David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA

  3. 3

    Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA

  4. 4

    Research and Development, Ferrosan Medical Devices A/S, Sydmarken 5, DK-2860, Denmark

*Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

Publication History

  1. Issue published online: 17 JAN 2012
  2. Article first published online: 27 DEC 2011
  3. Manuscript Revised: 12 NOV 2011
  4. Manuscript Received: 3 OCT 2011

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Keywords:

  • thrombin;
  • tannic acid;
  • layer-by-layer assembly;
  • bleeding;
  • hemostasis
Thumbnail image of graphical abstract

Spray layer-by-layer assembly is used to create hemostatic films containing thrombin and tannic acid. The spray assembly technique enables coating of porous and absorbent commercial gelatin sponges with these films. Coated sponges are able to promote instantaneous hemostasis in a porcine spleen bleeding model.

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