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Keywords:

  • thrombin;
  • tannic acid;
  • layer-by-layer assembly;
  • bleeding;
  • hemostasis
Thumbnail image of graphical abstract

Spray layer-by-layer assembly is used to create hemostatic films containing thrombin and tannic acid. The spray assembly technique enables coating of porous and absorbent commercial gelatin sponges with these films. Coated sponges are able to promote instantaneous hemostasis in a porcine spleen bleeding model.