Communication

Innovative Collagen Nano-Hydroxyapatite Scaffolds Offer a Highly Efficient Non-Viral Gene Delivery Platform for Stem Cell-Mediated Bone Formation

  1. Caroline M. Curtin1,2,
  2. Gráinne M. Cunniffe2,
  3. Frank G. Lyons1,
  4. Kazuhisa Bessho3,
  5. Glenn R. Dickson4,
  6. Garry P. Duffy1,2,
  7. Fergal J. O'Brien1,2,*

Article first published online: 2 JAN 2012

DOI: 10.1002/adma.201103828

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 6, pages 749–754, February 7, 2012

Additional Information

How to Cite

Curtin, C. M., Cunniffe, G. M., Lyons, F. G., Bessho, K., Dickson, G. R., Duffy, G. P. and O'Brien, F. J. (2012), Innovative Collagen Nano-Hydroxyapatite Scaffolds Offer a Highly Efficient Non-Viral Gene Delivery Platform for Stem Cell-Mediated Bone Formation. Adv. Mater., 24: 749–754. doi: 10.1002/adma.201103828

Author Information

  1. 1

    Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland

  2. 2

    Trinity Centre for Bioengineering, Trinity College Dublin, Ireland

  3. 3

    Department of Oral & Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Japan

  4. 4

    Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Northern Ireland

*Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland.

Publication History

  1. Issue published online: 31 JAN 2012
  2. Article first published online: 2 JAN 2012
  3. Manuscript Revised: 29 NOV 2011
  4. Manuscript Received: 4 OCT 2011

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Keywords:

  • biomedical applications;
  • biomineralization;
  • bionanotechnology;
  • tissue engineering;
  • composite materials
Thumbnail image of graphical abstract

The ability of nano-hydroxyapatite (nHA) particles developed in-house to act as non-viral delivery vectors is assessed. These nHA particles are combined with collagen to yield bioactive, biodegradable collagen nano-hydroxyapatite (coll-nHA) scaffolds. Their ability to act as gene-activated matrices for BMP2 delivery is demonstrated with successful transfection of mesenchymal stem cells (MSCs) resulting in high calcium production.

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