Design of Multifunctional Micelle for Tumor-Targeted Intracellular Drug Release and Fluorescent Imaging

Authors

  • Weiwei Wang,

    1. Center of Biomedical Engineering, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Du Cheng,

    1. PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Faming Gong,

    1. PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
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  • Xiangmin Miao,

    1. Center of Biomedical Engineering, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China
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  • Xintao Shuai

    Corresponding author
    1. Center of Biomedical Engineering, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China
    2. PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
    • Center of Biomedical Engineering, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
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Abstract

original image

A novel multifunctional polymeric micelle bearing a pH-tunable on-off module for programmed drug release, folate for tumor targeting, and quantum dots for fluorescent imaging is described. The micelle can turn drug release off at neutral pH whereas on inside lysosomes. QD functionalization allows a clear elucidation of pH-tunable drug release and facile visualization of in vivo delivery event.

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