Communication

Hierarchical Formation of Supramolecular Transient Networks in Water: A Modular Injectable Delivery System

  1. Patricia Y. W. Dankers1,2,3,
  2. Thomas M. Hermans1,4,
  3. Travis W. Baughman4,
  4. Yuko Kamikawa4,
  5. Roxanne E. Kieltyka1,3,
  6. Maartje M. C. Bastings1,3,
  7. Henk M. Janssen5,
  8. Nico A. J. M. Sommerdijk6,
  9. Antje Larsen7,
  10. Marja J. A. van Luyn2,
  11. Anton W. Bosman8,
  12. Eliane R. Popa2,
  13. George Fytas7,
  14. E. W. Meijer1,3,4,*

Article first published online: 23 APR 2012

DOI: 10.1002/adma.201104072

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 20, pages 2703–2709, May 22, 2012

Additional Information

How to Cite

Dankers, P. Y. W., Hermans, T. M., Baughman, T. W., Kamikawa, Y., Kieltyka, R. E., Bastings, M. M. C., Janssen, H. M., Sommerdijk, N. A. J. M., Larsen, A., van Luyn, M. J. A., Bosman, A. W., Popa, E. R., Fytas, G. and Meijer, E. W. (2012), Hierarchical Formation of Supramolecular Transient Networks in Water: A Modular Injectable Delivery System. Adv. Mater., 24: 2703–2709. doi: 10.1002/adma.201104072

Author Information

  1. 1

    Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands

  2. 2

    Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

  3. 3

    Laboratory of Chemical Biology, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands

  4. 4

    Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands

  5. 5

    SyMO-Chem BV, Den Dolech 2, 5612 AZ, Eindhoven, The Netherlands

  6. 6

    Soft Matter CryoTEM Research Unit, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands

  7. 7

    Department of Materials Science and Technology, University of Crete and F.O.R.T.H., PO Box 1527, 71110 Heraklion, Greece

  8. 8

    SupraPolix Research Center, Horsten 1, 5612 AX Eindhoven, The Netherlands

*Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands.

Publication History

  1. Issue published online: 15 MAY 2012
  2. Article first published online: 23 APR 2012
  3. Manuscript Received: 24 OCT 2011

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (1243K)

Keywords:

  • drug delivery;
  • transient networks;
  • biomedical applications;
  • self-assembly;
  • supramolecular polymers
Thumbnail image of graphical abstract

A modular one-component supramolecular transient network in water, based on poly(ethylene glycol) and end-capped with four-fold hydrogen bonding units, is reported. Due to its nonlinear structural formation, this system allows active proteins to be added to the hydrogel during formation. Once implanted in vivo it releases the protein by erosion of both the protein and polymer via dissolution.

View Full Article with Supporting Information (HTML) Get PDF (1243K)