Advanced Materials

Hierarchical Formation of Supramolecular Transient Networks in Water: A Modular Injectable Delivery System

Authors

  • Patricia Y. W. Dankers,

    1. Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    2. Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    3. Laboratory of Chemical Biology, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
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  • Thomas M. Hermans,

    1. Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    2. Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
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  • Travis W. Baughman,

    1. Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
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  • Yuko Kamikawa,

    1. Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
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  • Roxanne E. Kieltyka,

    1. Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    2. Laboratory of Chemical Biology, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
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  • Maartje M. C. Bastings,

    1. Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    2. Laboratory of Chemical Biology, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
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  • Henk M. Janssen,

    1. SyMO-Chem BV, Den Dolech 2, 5612 AZ, Eindhoven, The Netherlands
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  • Nico A. J. M. Sommerdijk,

    1. Soft Matter CryoTEM Research Unit, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
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  • Antje Larsen,

    1. Department of Materials Science and Technology, University of Crete and F.O.R.T.H., PO Box 1527, 71110 Heraklion, Greece
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  • Marja J. A. van Luyn,

    1. Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
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  • Anton W. Bosman,

    1. SupraPolix Research Center, Horsten 1, 5612 AX Eindhoven, The Netherlands
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  • Eliane R. Popa,

    1. Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
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  • George Fytas,

    1. Department of Materials Science and Technology, University of Crete and F.O.R.T.H., PO Box 1527, 71110 Heraklion, Greece
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  • E. W. Meijer

    Corresponding author
    1. Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    2. Laboratory of Chemical Biology, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    3. Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    • Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands.
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Abstract

A modular one-component supramolecular transient network in water, based on poly(ethylene glycol) and end-capped with four-fold hydrogen bonding units, is reported. Due to its nonlinear structural formation, this system allows active proteins to be added to the hydrogel during formation. Once implanted in vivo it releases the protein by erosion of both the protein and polymer via dissolution.

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