SEARCH

SEARCH BY CITATION

Keywords:

  • nanomedicine;
  • protein particles;
  • recombinant proteins;
  • cell therapy;
  • nanopills
Thumbnail image of graphical abstract

Inclusion bodies (50–500 nm in diameter) produced in recombinant bacteria can be engineered to contain functional proteins with therapeutic potential. Upon exposure, these protein particles are efficiently internalized by mammalian cells and promote recovery from diverse stresses. Being fully biocompatible, inclusion bodies are a novel platform, as tailored nanopills, for sustained drug release in advanced cell therapies.