Advanced Materials

Melanin-like Hydrogels Derived from Gallic Macromers

Authors

  • Omar Z. Fisher,

    1. David H. Koch Institute for Integrative Cancer Research, MIT Room 76-661, 77 Mass Ave, Cambridge, MA 02139-4307, USA
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  • Benjamin L. Larson,

    1. Harvard-MIT Division of Health Sciences and Technology, MIT Room 76-661, 77 Mass Ave, Cambridge, MA 02139-4307, USA
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  • Paulina S. Hill,

    1. David H. Koch Institute for Integrative Cancer Research, MIT Room 76-661, 77 Mass Ave, Cambridge, MA 02139-4307, USA
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  • David Graupner,

    1. David H. Koch Institute for Integrative Cancer Research, MIT Room 76-661, 77 Mass Ave, Cambridge, MA 02139-4307, USA
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  • Mai-Thi Nguyen-Kim,

    1. David H. Koch Institute for Integrative Cancer Research, MIT Room 76-661, 77 Mass Ave, Cambridge, MA 02139-4307, USA
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  • Nermin Seda Kehr,

    1. Physikalisches Institut and CeNTech, Westfälische Wilhelms-Universität Münster, Heisenbergstrasse 11, 48149 Münster, Germany
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  • Luisa De Cola,

    1. Physikalisches Institut and CeNTech, Westfälische Wilhelms-Universität Münster, Heisenbergstrasse 11, 48149 Münster, Germany
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  • Robert Langer,

    Corresponding author
    1. David H. Koch Institute for Integrative Cancer Research, MIT Room 76-661, 77 Mass Ave, Cambridge, MA 02139-4307, USA
    2. Harvard-MIT Division of Health Sciences and Technology, MIT Room 76-661, 77 Mass Ave, Cambridge, MA 02139-4307, USA
    3. Department of Chemical Engineering, Massachusetts Institute of Technology, MIT Room 76-661, 77 Mass Ave, Cambridge, MA 02139-4307, USA
    • David H. Koch Institute for Integrative Cancer Research, MIT Room 76-661, 77 Mass Ave, Cambridge, MA 02139-4307, USA.
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  • Daniel G. Anderson

    Corresponding author
    1. David H. Koch Institute for Integrative Cancer Research, MIT Room 76-661, 77 Mass Ave, Cambridge, MA 02139-4307, USA
    2. Harvard-MIT Division of Health Sciences and Technology, MIT Room 76-661, 77 Mass Ave, Cambridge, MA 02139-4307, USA
    3. Department of Chemical Engineering, Massachusetts Institute of Technology, MIT Room 76-661, 77 Mass Ave, Cambridge, MA 02139-4307, USA
    • David H. Koch Institute for Integrative Cancer Research, MIT Room 76-661, 77 Mass Ave, Cambridge, MA 02139-4307, USA.
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Abstract

The periodate oxidation of branched poly(ethylene glycol) macromers with gallate termini results in a hydrogel with melanin-like pigmentation and quinoid electrophilicity. This electrophilicity can be exploited for facile coupling with biomolecules.

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