Communication

Osteophilic Multilayer Coatings for Accelerated Bone Tissue Growth

  1. Nisarg J. Shah,
  2. Jinkee Hong,
  3. Md. Nasim Hyder,
  4. Paula T. Hammond*

Article first published online: 7 FEB 2012

DOI: 10.1002/adma.201104475

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 11, pages 1445–1450, March 15, 2012

Additional Information

How to Cite

Shah, N. J., Hong, J., Hyder, Md. N. and Hammond, P. T. (2012), Osteophilic Multilayer Coatings for Accelerated Bone Tissue Growth. Adv. Mater., 24: 1445–1450. doi: 10.1002/adma.201104475

Author Information

  1. Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer, Research and The Institute for Soldier, Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge, MA 02139 USA

*Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer, Research and The Institute for Soldier, Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge, MA 02139 USA.

Publication History

  1. Issue published online: 12 MAR 2012
  2. Article first published online: 7 FEB 2012
  3. Manuscript Revised: 30 DEC 2011
  4. Manuscript Received: 23 NOV 2011

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Keywords:

  • bone;
  • hydroxyapatite;
  • BMP-2;
  • osteoconductive;
  • layer-by-layer assembly
Thumbnail image of graphical abstract

Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants.

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