Advanced Materials

Osteophilic Multilayer Coatings for Accelerated Bone Tissue Growth

Authors

  • Nisarg J. Shah,

    1. Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer, Research and The Institute for Soldier, Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge, MA 02139 USA
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  • Jinkee Hong,

    1. Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer, Research and The Institute for Soldier, Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge, MA 02139 USA
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  • Md. Nasim Hyder,

    1. Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer, Research and The Institute for Soldier, Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge, MA 02139 USA
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  • Paula T. Hammond

    Corresponding author
    1. Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer, Research and The Institute for Soldier, Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge, MA 02139 USA
    • Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer, Research and The Institute for Soldier, Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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Abstract

Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants.

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