Communication

Mesoporous Silica-Coated Gold Nanorods as a Light-Mediated Multifunctional Theranostic Platform for Cancer Treatment

  1. Zhenjiang Zhang1,
  2. Liming Wang1,3,
  3. Jing Wang1,
  4. Xiumei Jiang1,
  5. Xiaohui Li1,
  6. Zhijian Hu2,
  7. Yinglu Ji2,
  8. Xiaochun Wu2,*,
  9. Chunying Chen1,*

Article first published online: 9 FEB 2012

DOI: 10.1002/adma.201104714

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 11, pages 1418–1423, March 15, 2012

Additional Information

How to Cite

Zhang, Z., Wang, L., Wang, J., Jiang, X., Li, X., Hu, Z., Ji, Y., Wu, X. and Chen, C. (2012), Mesoporous Silica-Coated Gold Nanorods as a Light-Mediated Multifunctional Theranostic Platform for Cancer Treatment. Adv. Mater., 24: 1418–1423. doi: 10.1002/adma.201104714

Author Information

  1. 1

    CAS Key Laboratory for Biomedical, Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No.11 Zhongguancun Beiyitiao, Beijing 100190, China

  2. 2

    CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, No.11 Zhongguancun Beiyitiao, Beijing 100190, China

  3. 3

    Institute of High Energy Physics, Chinese Academy of Sciences, No.19B Yuquanlu, Beijing 100049, China

*CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, No.11 Zhongguancun Beiyitiao, Beijing 100190, China

Publication History

  1. Issue published online: 12 MAR 2012
  2. Article first published online: 9 FEB 2012
  3. Manuscript Revised: 26 DEC 2011
  4. Manuscript Received: 10 DEC 2011

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Keywords:

  • silica-coated gold nanorods;
  • theranostics;
  • light-controlled drug release;
  • chemotherapy;
  • hyperthermia
Thumbnail image of graphical abstract

Mesoporous silica-coated gold nanorods (Au@SiO2) are developed as a promising and versatile theranostic platform for cancer treatment. Intracellular localization of Au@SiO2 is visualized through two-photon imaging. With doxorubicin hydrochloride loaded, Au@SiO2–DOX show two light-mediated therapeutic modes: low power density laser-triggered drug release for chemotherapy, and high power density laser-induced hyperthermia, which suggest the potential for in-vivo applications.

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