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Advanced Materials

Mesoporous Silica-Coated Gold Nanorods as a Light-Mediated Multifunctional Theranostic Platform for Cancer Treatment

Authors

  • Zhenjiang Zhang,

    1. CAS Key Laboratory for Biomedical, Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No.11 Zhongguancun Beiyitiao, Beijing 100190, China
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  • Liming Wang,

    1. CAS Key Laboratory for Biomedical, Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No.11 Zhongguancun Beiyitiao, Beijing 100190, China
    2. Institute of High Energy Physics, Chinese Academy of Sciences, No.19B Yuquanlu, Beijing 100049, China
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  • Jing Wang,

    1. CAS Key Laboratory for Biomedical, Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No.11 Zhongguancun Beiyitiao, Beijing 100190, China
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  • Xiumei Jiang,

    1. CAS Key Laboratory for Biomedical, Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No.11 Zhongguancun Beiyitiao, Beijing 100190, China
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  • Xiaohui Li,

    1. CAS Key Laboratory for Biomedical, Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No.11 Zhongguancun Beiyitiao, Beijing 100190, China
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  • Zhijian Hu,

    1. CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, No.11 Zhongguancun Beiyitiao, Beijing 100190, China
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  • Yinglu Ji,

    1. CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, No.11 Zhongguancun Beiyitiao, Beijing 100190, China
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  • Xiaochun Wu,

    Corresponding author
    1. CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, No.11 Zhongguancun Beiyitiao, Beijing 100190, China
    • CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, No.11 Zhongguancun Beiyitiao, Beijing 100190, China
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  • Chunying Chen

    Corresponding author
    1. CAS Key Laboratory for Biomedical, Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No.11 Zhongguancun Beiyitiao, Beijing 100190, China
    • CAS Key Laboratory for Biomedical, Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No.11 Zhongguancun Beiyitiao, Beijing 100190, China.
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Abstract

Mesoporous silica-coated gold nanorods (Au@SiO2) are developed as a promising and versatile theranostic platform for cancer treatment. Intracellular localization of Au@SiO2 is visualized through two-photon imaging. With doxorubicin hydrochloride loaded, Au@SiO2–DOX show two light-mediated therapeutic modes: low power density laser-triggered drug release for chemotherapy, and high power density laser-induced hyperthermia, which suggest the potential for in-vivo applications.

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