Mesoporous silica-coated gold nanorods (Au@SiO2) are developed as a promising and versatile theranostic platform for cancer treatment. Intracellular localization of Au@SiO2 is visualized through two-photon imaging. With doxorubicin hydrochloride loaded, Au@SiO2–DOX show two light-mediated therapeutic modes: low power density laser-triggered drug release for chemotherapy, and high power density laser-induced hyperthermia, which suggest the potential for in-vivo applications.
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