Communication

Mn2+ Dopant-Controlled Synthesis of NaYF4:Yb/Er Upconversion Nanoparticles for in vivo Imaging and Drug Delivery

  1. Gan Tian1,3,
  2. Zhanjun Gu1,*,
  3. Liangjun Zhou1,4,
  4. Wenyan Yin1,
  5. Xiaoxiao Liu1,
  6. Liang Yan1,
  7. Shan Jin1,4,
  8. Wenlu Ren1,
  9. Gengmei Xing1,
  10. Shoujian Li3,
  11. Yuliang Zhao1,2,*

Article first published online: 27 JAN 2012

DOI: 10.1002/adma.201104741

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 9, pages 1226–1231, March 2, 2012

Additional Information

How to Cite

Tian, G., Gu, Z., Zhou, L., Yin, W., Liu, X., Yan, L., Jin, S., Ren, W., Xing, G., Li, S. and Zhao, Y. (2012), Mn2+ Dopant-Controlled Synthesis of NaYF4:Yb/Er Upconversion Nanoparticles for in vivo Imaging and Drug Delivery. Adv. Mater., 24: 1226–1231. doi: 10.1002/adma.201104741

Author Information

  1. 1

    Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China

  2. 2

    Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing 100190, China

  3. 3

    College of Chemistry, Sichuan University, Chengdu, 610064, P. R. China

  4. 4

    College of Materials Science and Opto-Electronic Technology, Graduate University of Chinese Academy of Sciences, Beijing 100049, P. R. China

*Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China.

Publication History

  1. Issue published online: 24 FEB 2012
  2. Article first published online: 27 JAN 2012
  3. Manuscript Revised: 5 JAN 2012
  4. Manuscript Received: 12 DEC 2011

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Keywords:

  • NaYF4:Yb/Er;
  • Mn2+-doping;
  • single-band red upconversion emission;
  • in vivo imaging;
  • drug delivery
Thumbnail image of graphical abstract

Pure dark red emission (650–670nm) of NaYF4:Yb/Er upconversion nanoparticles (UCNPs) is achieved by manganese ions (Mn2+) doping. In addition, the Mn2+- doping can also control the crystalline phase and size of the resulting UCNPs simultaneously. Drug delivery studies suggest the promise of these UCNPs as drug carriers for intracellular drug delivery and eventually as a multifunctional nanoplatform for simultaneous diagnosis and therapy.

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