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Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles

Authors

  • Xinjian Yang,

    1. Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625
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  • Xia Liu,

    1. Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625
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  • Zhen Liu,

    1. Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625
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  • Fang Pu,

    1. Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625
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  • Jinsong Ren,

    Corresponding author
    1. Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625
    • Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625.
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  • Xiaogang Qu

    Corresponding author
    1. Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625
    • Laboratory of Chemical Biology and State Key, Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin 130022, China, Fax: 86-431-85262625.
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Abstract

A novel cell-targeting, near-infrared light-responsive drug delivery platform based on mesoporous silica-coated gold nanorods that are surface-functionalized with aptamer DNA is constructed. Aptamer DNA is used as both capping and targeting agent. In vitro studies show the feasibility of using this nanocarrier for targeted and noninvasive remote controlled drug delivery and photothermal therapy.

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