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This is a Special Issue dedicated to Tsinghua University (Beijing, China) on the occasion of her Centennial Anniversary. It includes eleven papers covering nanomaterials research, carbon-based materials, organic optoelectronics, metallic materials, and functional soft materials, reflecting the wealth of ways in which chemistry and physics are at play to produce advanced materials at Tsinghua University. Cover design by Fang Liu, and photography by Rui Li.