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A “Living” Microvascular Stamp: “Living” Microvascular Stamp for Patterning of Functional Neovessels; Orchestrated Control of Matrix Property and Geometry (Adv. Mater. 1/2012)

  1. Jae Hyun Jeong3,
  2. Vincent Chan4,
  3. Chaenyung Cha3,
  4. Pinar Zorlutuna4,
  5. Casey Dyck5,
  6. K. Jimmy Hsia4,5,6,
  7. Rashid Bashir2,4,6,7,*,
  8. Hyunjoon Kong1,3,6,7,*

Article first published online: 29 DEC 2011

DOI: 10.1002/adma.201190202

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 1, page 1, January 3, 2012

Additional Information

How to Cite

Jeong, J. H., Chan, V., Cha, C., Zorlutuna, P., Dyck, C., Hsia, K. J., Bashir, R. and Kong, H. (2012), A “Living” Microvascular Stamp: “Living” Microvascular Stamp for Patterning of Functional Neovessels; Orchestrated Control of Matrix Property and Geometry (Adv. Mater. 1/2012). Adv. Mater., 24: 1. doi: 10.1002/adma.201190202

Author Information

  1. 1

    Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA

  2. 2

    Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA

  3. 3

    Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA

  4. 4

    Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA

  5. 5

    Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA

  6. 6

    Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA

  7. 7

    Institute of Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA

*Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

Publication History

  1. Issue published online: 29 DEC 2011
  2. Article first published online: 29 DEC 2011

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Keywords:

  • angiogenesis;
  • patterned neovessels;
  • methacrylic alginate;
  • stereolithography;
  • cell-encapsulation
Thumbnail image of graphical abstract

Orchestrated control of matrix property and geometry is reported by Rashid Bashir, Hyunjoon Kong, and co-workers on page 58. The “living” microvascular stamp releases multiple angiogenic factors and subsequently creates functional neo-vessels with the same pattern as that engraved in the stamp. The stamp consists of live cells that secrete angiogenic factors, an engineered hydrogel matrix that promotes cellular expression of angiogenic factors, and a three-dimensional geometry that localizes the angiogenic factors within the pattern.

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