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Bioactive Hydrogels: Maleimide Cross-Linked Bioactive PEG Hydrogel Exhibits Improved Reaction Kinetics and Cross-Linking for Cell Encapsulation and In Situ Delivery (Adv. Mater. 1/2012)

Authors

  • Edward A. Phelps,

    1. Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332-0363, USA
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  • Nduka O. Enemchukwu,

    1. Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332-0363, USA
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  • Vincent F. Fiore,

    1. Coulter Department of Biomedical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332-0363, USA
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  • Jay C. Sy,

    1. Coulter Department of Biomedical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332-0363, USA
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  • Niren Murthy,

    1. Coulter Department of Biomedical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332-0363, USA
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  • Todd A. Sulchek,

    1. Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332-0363, USA
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  • Thomas H. Barker,

    1. Coulter Department of Biomedical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332-0363, USA
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  • Andrés J. García

    Corresponding author
    1. Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332-0363, USA
    • Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332-0363, USA.
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Abstract

original image

The cover image shows a biofunctionalized hydrogel that is bonded directly onto myocardial tissue, delivering regenerative cells and therapeutics. On page 64, Andrés García and co-workers describe how maleimide-based cross-linking improves polyethylene glycol hydrogel engineering, leading to rapid gelation, high cytocom-patibility, and facile in situ delivery.

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