Communication

Self-Assembled Peptide Amphiphile Micelles Containing a Cytotoxic T-Cell Epitope Promote a Protective Immune Response In Vivo

  1. Matthew Black2,†,
  2. Amanda Trent3,†,
  3. Yulia Kostenko4,
  4. Joseph Saeyong Lee4,
  5. Colleen Olive5,
  6. Matthew Tirrell1,*

Article first published online: 2 MAY 2012

DOI: 10.1002/adma.201200209

Issue

Advanced Materials

Advanced Materials

Special Issue: Materials for Drug Delivery: Innovative Solutions to Address Complex Biological Hurdles

Volume 24, Issue 28, pages 3845–3849, July 24, 2012

Additional Information

How to Cite

Black, M., Trent, A., Kostenko, Y., Lee, J. S., Olive, C. and Tirrell, M. (2012), Self-Assembled Peptide Amphiphile Micelles Containing a Cytotoxic T-Cell Epitope Promote a Protective Immune Response In Vivo. Adv. Mater., 24: 3845–3849. doi: 10.1002/adma.201200209

Author Information

  1. 1

    Institute for Molecular Engineering, University of Chicago, Searle Chemistry Laboratory, Room 402, 5735 South Ellis, Avenue, Chicago, IL 60637, USA

  2. 2

    Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA

  3. 3

    Biomolecular Science and Engineering Program, University of California, Santa Barbara, Santa Barbara, CA 93106, USA

  4. 4

    Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94709, USA

  5. 5

    Immunity and Vaccinology Laboratory, The Queensland Institute of Medical Research, Brisbane QLD 4029, Australia

  1. †

    These authors contributed equally to this work

*Institute for Molecular Engineering, University of Chicago, Searle Chemistry Laboratory, Room 402, 5735 South Ellis, Avenue, Chicago, IL 60637, USA.

Publication History

  1. Issue published online: 17 JUL 2012
  2. Article first published online: 2 MAY 2012
  3. Manuscript Revised: 20 FEB 2012
  4. Manuscript Received: 15 JAN 2012

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Keywords:

  • biomolecular materials;
  • micelles;
  • nanoparticles;
  • peptide amphiphiles;
  • immunotherapy
Thumbnail image of graphical abstract

A model cytotoxic T-cell epitope is linked to a synthetic lipid tail, forming a peptide amphiphile that self-assembles into cylindrical micelles. The micelles are capable of inducing a cytotoxic T-cell response in mice that slows the growth of tumors expressing the tumor antigen.

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