Communication “Advanced Optical Materials”

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Label-Free, Coupler-Free, Scalable and Intracellular Bio-imaging by Multimode Plasmonic Resonances in Split-Ring Resonators

  1. Yueh-Chun Lai1,
  2. Hsin-Cheng Lee1,
  3. Shu-Wen Kuo2,
  4. Cheng-Kuang Chen1,
  5. Hsieh-Ting Wu1,
  6. Oscar K. Lee2,
  7. Ta-Jen Yen1,*

Article first published online: 15 MAY 2012

DOI: 10.1002/adma.201200291

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 23, pages OP148–OP152, June 19, 2012

Additional Information

How to Cite

Lai, Y.-C., Lee, H.-C., Kuo, S.-W., Chen, C.-K., Wu, H.-T., Lee, O. K. and Yen, T.-J. (2012), Label-Free, Coupler-Free, Scalable and Intracellular Bio-imaging by Multimode Plasmonic Resonances in Split-Ring Resonators. Adv. Mater., 24: OP148–OP152. doi: 10.1002/adma.201200291

Author Information

  1. 1

    Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan

  2. 2

    Institute of Clinical Medicine, National Yang-Ming University, Taipei 11221, Taiwan

*Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan.

Publication History

  1. Issue published online: 12 JUN 2012
  2. Article first published online: 15 MAY 2012
  3. Manuscript Revised: 27 FEB 2012
  4. Manuscript Received: 20 JAN 2012

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Keywords:

  • plasmonics;
  • metamaterials;
  • split-ring resonators;
  • biosensors;
  • bioimaging
Thumbnail image of graphical abstract

Intracellular imaging by exciting multimode resonances in spilt-ring resonators (SRRs) is presented. With advantages such as being label-free, coupler-free, having a tunable spectrum range and intracellular detection length, SRR microscopy is a strong competitor for surface plasmon resonance microscopy for observing cells. Its capability for constructing refractive index distribution images of cells is demonstrated. SRR microscopy offers a much simpler optical configuration and better penetration depth for truly whole-cell imaging applications.

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