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Label-Free, Coupler-Free, Scalable and Intracellular Bio-imaging by Multimode Plasmonic Resonances in Split-Ring Resonators

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Abstract

Intracellular imaging by exciting multimode resonances in spilt-ring resonators (SRRs) is presented. With advantages such as being label-free, coupler-free, having a tunable spectrum range and intracellular detection length, SRR microscopy is a strong competitor for surface plasmon resonance microscopy for observing cells. Its capability for constructing refractive index distribution images of cells is demonstrated. SRR microscopy offers a much simpler optical configuration and better penetration depth for truly whole-cell imaging applications.

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