Multicompartmental Particles for Combined Imaging and siRNA Delivery

Authors

  • Asish C Misra,

    1. Department of Biomedical Engineering, The University of Michigan, 2300 Hayward St., Ann Arbor, MI 48109, USA
    2. The University of Michigan Medical School, 2300 Hayward St., Ann Arbor, MI 48109, USA
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  • Srijanani Bhaskar,

    1. Department of Macromolecular Science and Engineering, The University of Michigan, 2300 Hayward St., Ann Arbor, MI 48109, USA
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  • Nicholas Clay,

    1. Department of Chemical Engineering, 3414 GGBL2300 Hayward, Ann Arbor, MI 4809, USA
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  • Joerg Lahann

    Corresponding author
    1. Department of Biomedical Engineering, The University of Michigan, 2300 Hayward St., Ann Arbor, MI 48109, USA
    2. Department of Macromolecular Science and Engineering, The University of Michigan, 2300 Hayward St., Ann Arbor, MI 48109, USA
    3. Department of Chemical Engineering, 3414 GGBL2300 Hayward, Ann Arbor, MI 4809, USA
    4. Department of Materials Science and Engineering, The University of Michigan, 2300 Hayward St., Ann Arbor, MI 48109, USA
    • Department of Biomedical Engineering, The University of Michigan, 2300 Hayward St., Ann Arbor, MI 48109, USA.
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Abstract

original image

Multifunctional, multicompartmental particles can be fabricated by electrohydrodynamic co-jetting, capable of both imaging and siRNA delivery. These particles are able to sense and respond to the endosomal environment allowing for effective delivery of siRNA.

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