Communication

Three-Dimensional Biomimetic Patterning in Hydrogels to Guide Cellular Organization

  1. James C. Culver1,†,
  2. Joseph C. Hoffmann2,†,
  3. Ross A. Poché1,
  4. John H. Slater2,
  5. Jennifer L. West2,*,
  6. Mary E. Dickinson1,*

Article first published online: 30 MAR 2012

DOI: 10.1002/adma.201200395

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 17, pages 2344–2348, May 2, 2012

Additional Information

How to Cite

Culver, J. C., Hoffmann, J. C., Poché, R. A., Slater, J. H., West, J. L. and Dickinson, M. E. (2012), Three-Dimensional Biomimetic Patterning in Hydrogels to Guide Cellular Organization. Adv. Mater., 24: 2344–2348. doi: 10.1002/adma.201200395

Author Information

  1. 1

    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

  2. 2

    Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX, 77005, USA

  1. †

    These authors contributed equally to this work.

*Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX, 77005, USA

Publication History

  1. Issue published online: 23 APR 2012
  2. Article first published online: 30 MAR 2012
  3. Manuscript Received: 28 JAN 2012

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Keywords:

  • tissue engineering;
  • photolithography;
  • hydrogel;
  • two-photon microscopy;
  • vascular niche
Thumbnail image of graphical abstract

An image-guided micropatterning method is demonstrated for generating biomimetic hydrogel scaffolds with two-photon laser scanning photolithography. This process utilizes computational methods to directly translate three-dimensional cytoarchitectural features from labeled tissues into material structures. We use this method to pattern hydrogels that guide cellular organization by structurally and biochemically recapitulating complex vascular niche microenvironments with high pattern fidelity at the microscale.

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