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Platelet Mimetic Particles for Targeting Thrombi in Flowing Blood

Authors

  • Nishit Doshi,

    1. Department of Chemical Engineering, University of California, Santa Barbara, CA
    Current affiliation:
    1. These two authors contributed equally to the work.
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  • Jennifer N. Orje,

    1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Current affiliation:
    1. These two authors contributed equally to the work.
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  • Blanca Molins,

    1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Current affiliation:
    1. Cardiovascular Research Center, CSIC-ICCC, Institut Investigacions Biomèdiques Sant Pau, Hospital de la Santa Creu i Sant Pau, C/Sant Antoni Ma Claret 167, 08025 Barcelona, Spain
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  • Jeffrey W. Smith,

    1. The Sanford-Burnham Institute, La Jolla, CA, USA
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  • Samir Mitragotri,

    Corresponding author
    1. Department of Chemical Engineering, University of California, Santa Barbara, CA
    • Department of Chemical Engineering, University of California, Santa Barbara, CA
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  • Zaverio M. Ruggeri

    Corresponding author
    1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    • Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.
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Abstract

Platelets are a paradigm for a drug carrier in blood owing to their unique physical and biochemical properties. Here, we report the development of synthetic particles that mimic several physical features and important functional properties of platelets. These synthetic platelets have therapeutic and diagnostic applications for platelet associated disorders.

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