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Keywords:

  • mesoporous silica;
  • nanoporous polymer particles;
  • drug delivery;
  • neurotrophic factors;
  • sensorineural hearing loss
Thumbnail image of graphical abstract

Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons (as indicated by the arrows) in the cochlea of guinea pigs with sensorineural hearing loss.