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Nanoporous Peptide Particles for Encapsulating and Releasing Neurotrophic Factors in an Animal Model of Neurodegeneration

Authors

  • Justin Tan,

    1. Bionics Institute, East Melbourne, Victoria 3002, Australia
    2. Department of Otolaryngology, The University of Melbourne, East Melbourne, Victoria 3002, Australia
    Current affiliation:
    1. J. Tan and Y. Wang contributed equally.
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  • Yajun Wang,

    1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
    Current affiliation:
    1. J. Tan and Y. Wang contributed equally.
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  • Xiaopei Yip,

    1. Bionics Institute, East Melbourne, Victoria 3002, Australia
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  • Fergal Glynn,

    1. Bionics Institute, East Melbourne, Victoria 3002, Australia
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  • Robert K. Shepherd,

    1. Bionics Institute, East Melbourne, Victoria 3002, Australia
    2. Department of Otolaryngology, The University of Melbourne, East Melbourne, Victoria 3002, Australia
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  • Frank Caruso

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
    • Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
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Abstract

Neurotrophin-BDNF can be effectively encapsulated in nanoporous poly(L-glutamic acid) particles prepared via mesoporous silica templating. The loaded BDNF can be released in a sustained manner with retained biological activity. Animal experiments demonstrate the released BDNF can efficiently rescue the auditory neurons (as indicated by the arrows) in the cochlea of guinea pigs with sensorineural hearing loss.

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