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Light-Triggered Theranostics Based on Photosensitizer-Conjugated Carbon Dots for Simultaneous Enhanced-Fluorescence Imaging and Photodynamic Therapy

Authors

  • Peng Huang,

    1. Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China
    2. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, 31 Center Dr., Suite 1C14, Bethesda, MD 20892-2281, USA
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  • Jing Lin,

    1. Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China
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  • Xiansong Wang,

    1. Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China
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  • Zhe Wang,

    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, 31 Center Dr., Suite 1C14, Bethesda, MD 20892-2281, USA
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  • Chunlei Zhang,

    1. Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China
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  • Meng He,

    1. Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China
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  • Kan Wang,

    1. Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China
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  • Feng Chen,

    1. Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China
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  • Zhiming Li,

    1. Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China
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  • Guangxia Shen,

    Corresponding author
    1. Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China
    • Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China
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  • Daxiang Cui,

    Corresponding author
    1. Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China
    • Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, PR China
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  • Xiaoyuan Chen

    Corresponding author
    1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, 31 Center Dr., Suite 1C14, Bethesda, MD 20892-2281, USA
    2. Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China
    • Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, 31 Center Dr., Suite 1C14, Bethesda, MD 20892-2281, USA.
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Abstract

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Novel theranostics based on photosensitizer-conjugated carbon dots is reported. The prepared C-dots–Ce6 has good stability and high water dispersibility and solubility, non-cytotoxicity, good biocompatibility, enhanced photosensitizer fluorescence detection and remarkable photodynamic efficacy upon irradiation. The C-dots–Ce6 conjugate is a good candidate with excellent imaging and tumor-homing ability for NIR fluorescence imaging monitored PDT treatment.

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