Advanced Materials

A Novel Bioassay Platform Using Ferritin-Based Nanoprobe Hydrogel

Authors

  • Eun Jung Lee,

    1. Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul 136-713, Republic of Korea
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  • Keum-Young Ahn,

    1. Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul 136-713, Republic of Korea
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  • Jong-Hwan Lee,

    1. Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul 136-713, Republic of Korea
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  • Jin-Seung Park,

    1. Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul 136-713, Republic of Korea
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  • Jong-Am Song,

    1. Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul 136-713, Republic of Korea
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  • Sang Jun Sim,

    1. Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul 136-713, Republic of Korea
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  • Eun Bong Lee,

    1. College of Medicine, Seoul National University, Daehak-Ro 103, Seoul 110-744, Republic of Korea
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  • Young Joo Cha,

    1. College of Medicine, Chung-ang University, Heuksuk-Ro 84, Seoul 156-756, Republic of Korea
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  • Jeewon Lee

    Corresponding author
    1. Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul 136-713, Republic of Korea
    • Department of Chemical and Biological Engineering, College of Engineering, Korea University, Anam-Ro 145, Seoul 136-713, Republic of Korea.
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Abstract

Ferritin-based nanoprobe (FBNP) hydrogel provides solutions to some of the traditional problems of bioassays. The schematic shows 3D and highly specific multiplex assays of markers for AIDS and Sjögren's syndrome using quantum-dot based reporters with different fluorescence emissions for the two syndromes. The advantages of using a hydrogel include that the stability of FBNPs is significantly enhanced within the hydrogel, FBNPs are distributed evenly throughout the hydrogel matrix, and the amount of FBNPs within the hydrogel can be well controlled.

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