Microfibers Fabricated by Non-Covalent Assembly of Peptide and DNA for Viral Vector Encapsulation and Cancer Therapy

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Abstract

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Self-assembled amphiphilic peptide units and supercoiled, circular double-stranded plasmid DNA are used as building blocks to form peptide/DNA fibers for virus encapsulation. Since the fiber formation process takes place under ambient conditions and is aqueous-based without the use of denaturing organic solvents, the bioactivity of viruses is well preserved.

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