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Keywords:

  • microfluidic spinning;
  • fibers;
  • microstructures;
  • patterned;
  • ribbons;
  • grooved;
  • cell alignment;
  • alginates
Thumbnail image of graphical abstract

Alginate microribbons with longitudinally grooved microstructures are continuously fabricated by means of a microfluidic system. The number and dimensions of the microgroovesare successfully controlled by regulation of the slit-shaped channel (yellow in figure). This method opens up the possibility of mass production of scaffolds for tissue engineering purposes, as it is proved that the grooved flat fibers can be used to align other types of cells in culture.