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Keywords:

  • hydrogels;
  • hierarchical materials;
  • biomaterials;
  • encoding;
  • 3D cell culture;
  • 3D tissues
Thumbnail image of graphical abstract

The one-step, continuous formation of mosaic hydrogel sheets is presented. A microfluidic device allows controllable incorporation of secondary biopolymers within a flowing biopolymer sheet followed by a cross-linking step that retains the microscale composition. Information is encoded; mosaic stiffness and diffusivity patterns are created; tessellations are populated with biomolecules, microparticles and viable primary cells; and 3D soft material assemblies are demonstrated.