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Communication

Mosaic Hydrogels: One-Step Formation of Multiscale Soft Materials

  1. Lian Leng1,
  2. Arianna McAllister2,
  3. Boyang Zhang2,3,
  4. Milica Radisic2,3,
  5. Axel Günther1,2,*

Article first published online: 20 JUN 2012

DOI: 10.1002/adma.201201442

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 27, pages 3650–3658, July 17, 2012

Additional Information

How to Cite

Leng, L., McAllister, A., Zhang, B., Radisic, M. and Günther, A. (2012), Mosaic Hydrogels: One-Step Formation of Multiscale Soft Materials. Adv. Mater., 24: 3650–3658. doi: 10.1002/adma.201201442

Author Information

  1. 1

    Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, Ontario, M5S3G8, Canada

  2. 2

    Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario, M5S 3G9, Canada

  3. 3

    Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario, M5S 3E5, Canada

*Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, Ontario, M5S3G8, Canada.

Publication History

  1. Issue published online: 10 JUL 2012
  2. Article first published online: 20 JUN 2012
  3. Manuscript Revised: 10 MAY 2012
  4. Manuscript Received: 10 APR 2012

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Keywords:

  • hydrogels;
  • hierarchical materials;
  • biomaterials;
  • encoding;
  • 3D cell culture;
  • 3D tissues
Thumbnail image of graphical abstract

The one-step, continuous formation of mosaic hydrogel sheets is presented. A microfluidic device allows controllable incorporation of secondary biopolymers within a flowing biopolymer sheet followed by a cross-linking step that retains the microscale composition. Information is encoded; mosaic stiffness and diffusivity patterns are created; tessellations are populated with biomolecules, microparticles and viable primary cells; and 3D soft material assemblies are demonstrated.

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