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Advanced Materials

Coordination Polymer Coated Mesoporous Silica Nanoparticles for pH-Responsive Drug Release

Authors

  • Lei Xing,

    1. School of Chemistry and Chemical Engineering, State Key Laboratory Metal Matrix Composites, Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
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  • Haoquan Zheng,

    1. School of Chemistry and Chemical Engineering, State Key Laboratory Metal Matrix Composites, Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
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  • Yuanyuan Cao,

    1. School of Chemistry and Chemical Engineering, State Key Laboratory Metal Matrix Composites, Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
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  • Shunai Che

    Corresponding author
    1. School of Chemistry and Chemical Engineering, State Key Laboratory Metal Matrix Composites, Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
    • School of Chemistry and Chemical Engineering, State Key Laboratory Metal Matrix Composites, Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
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Abstract

Coordination polymer coated mesoporous silica nanoparticles for drug delivery are successfully synthesized. The system ensures that drugs are stored in the mesopores under a physiological environment. Upon H+ stimulus in the endosomal and lysosomal compartments, the drugs are released into the intracellular organelles of cancer cells, effectively killing the cells.

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