Communication

Rapid Fabrication of Complex 3D Extracellular Microenvironments by Dynamic Optical Projection Stereolithography

  1. A. Ping Zhang1,2,*,
  2. Xin Qu1,
  3. Pranav Soman1,
  4. Kolin C. Hribar1,
  5. Jin W. Lee1,
  6. Shaochen Chen1,*,
  7. Sailing He2

Article first published online: 12 JUL 2012

DOI: 10.1002/adma.201202024

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 31, pages 4266–4270, August 16, 2012

Additional Information

How to Cite

Zhang, A. P., Qu, X., Soman, P., Hribar, K. C., Lee, J. W., Chen, S. and He, S. (2012), Rapid Fabrication of Complex 3D Extracellular Microenvironments by Dynamic Optical Projection Stereolithography. Adv. Mater., 24: 4266–4270. doi: 10.1002/adma.201202024

Author Information

  1. 1

    Department of NanoEngineering, University of California, San Diego, CA 92093, USA

  2. 2

    Centre for Optical and Electromagnetic Research, State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310058, P. R. China

*Department of NanoEngineering, University of California, San Diego, CA 92093, USA.

Publication History

  1. Issue published online: 6 AUG 2012
  2. Article first published online: 12 JUL 2012
  3. Manuscript Received: 21 MAY 2012

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Keywords:

  • extracelluar microenviroment;
  • cell culture;
  • soft material;
  • optical projection stereolithography;
  • maskless lithography
Thumbnail image of graphical abstract

The topographic features of the extracelluar matrix (ECM) lay the foundation for cellular behavior. A novel biofabrication method using a digital-mirror device (DMD), called dynamic optical projection stereolithography (DOPsL) is demonstrated. This robust and versatile platform can generate complex biomimetic scaffolds within seconds. Such 3D scaffolds have promising potentials for studying cell interactions with microenvironments in vitro and in vivo.

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