Get access

Molecular Catch and Release: Controlled Delivery Using Optical Trapping with Light-Responsive Liposomes

Authors

  • Sarah J. Leung,

    1. Department of Biomedical Engineering, University of Arizona, 1657 E. Helen Street, Tucson, AZ 85721, USA, Fax: 520-626-4824
    Search for more papers by this author
  • Marek Romanowski

    Corresponding author
    1. Department of Biomedical Engineering, University of Arizona, 1657 E. Helen Street, Tucson, AZ 85721, USA, Fax: 520-626-4824
    • Department of Biomedical Engineering, University of Arizona, 1657 E. Helen Street, Tucson, AZ 85721, USA, Fax: 520-626-4824.
    Search for more papers by this author

Abstract

original image

Gold-coated liposomes are maneuvered using an optical trap to achieve precise delivery of encapsulated molecular cargo. Movement and payload release from these plasmon resonant nanocapsules are independently controlled using a pulsed trapping beam. This technology enables in vitro delivery of a payload to a selected cell and may be applied to the interrogation of individual cells within their biological microenvironment.

Ancillary