Communication

Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor

  1. You-Yong Yuan1,†,
  2. Cheng-Qiong Mao1,†,
  3. Xiao-Jiao Du1,
  4. Jin-Zhi Du2,
  5. Feng Wang1,
  6. Jun Wang1,*

Article first published online: 9 AUG 2012

DOI: 10.1002/adma.201202296

Issue

Advanced Materials

Advanced Materials

Volume 24, Issue 40, pages 5476–5480, October 23, 2012

Additional Information

How to Cite

Yuan, Y.-Y., Mao, C.-Q., Du, X.-J., Du, J.-Z., Wang, F. and Wang, J. (2012), Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor. Adv. Mater., 24: 5476–5480. doi: 10.1002/adma.201202296

Author Information

  1. 1

    Hefei National Laboratory for Physical, Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P.R. China, Fax: (+) 86 551 3600402

  2. 2

    CAS Key Laboratory of Soft Matter Chemistry and Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P.R. China

  1. †

    These authors contributed equally to this work.

*Hefei National Laboratory for Physical, Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P.R. China, Fax: (+) 86 551 3600402.

Publication History

  1. Issue published online: 12 OCT 2012
  2. Article first published online: 9 AUG 2012
  3. Manuscript Revised: 25 JUN 2012
  4. Manuscript Received: 7 JUN 2012

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Keywords:

  • controlled release;
  • drug delivery;
  • micelles;
  • pH-responsive polymer;
  • zwitterionic
Thumbnail image of graphical abstract

Two faced nanoparticles: A zwitterionic polymer-based nanoparticle with response to tumor acidity is developed for enhanced drug delivery to tumors. The nanoparticles are neutrally charged at physiological conditions and show prolonged circulation time; after leaking into tumor sites, in the acidic extracellular tumor environment (pHe), nanoparticles are activated and become positively charged and are therefore efficiently taken up by tumor cells, leading to enhanced therapeutic effects in cancer treatment.

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