Advanced Materials

Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor

Authors

  • You-Yong Yuan,

    1. Hefei National Laboratory for Physical, Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P.R. China, Fax: (+) 86 551 3600402
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Cheng-Qiong Mao,

    1. Hefei National Laboratory for Physical, Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P.R. China, Fax: (+) 86 551 3600402
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Xiao-Jiao Du,

    1. Hefei National Laboratory for Physical, Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P.R. China, Fax: (+) 86 551 3600402
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  • Jin-Zhi Du,

    1. CAS Key Laboratory of Soft Matter Chemistry and Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P.R. China
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  • Feng Wang,

    1. Hefei National Laboratory for Physical, Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P.R. China, Fax: (+) 86 551 3600402
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  • Jun Wang

    Corresponding author
    1. Hefei National Laboratory for Physical, Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P.R. China, Fax: (+) 86 551 3600402
    • Hefei National Laboratory for Physical, Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P.R. China, Fax: (+) 86 551 3600402.
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Abstract

Two faced nanoparticles: A zwitterionic polymer-based nanoparticle with response to tumor acidity is developed for enhanced drug delivery to tumors. The nanoparticles are neutrally charged at physiological conditions and show prolonged circulation time; after leaking into tumor sites, in the acidic extracellular tumor environment (pHe), nanoparticles are activated and become positively charged and are therefore efficiently taken up by tumor cells, leading to enhanced therapeutic effects in cancer treatment.

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